What are glucosamine and chondroitin?
For over two decades there has been a debate in the treatment of osteoarthritis about the use of the joint supplements glucosamine and chondroitin. Osteoarthritis is a condition that causes problems of wearing out of the normal smooth cartilage surfaces of the joints. Often called wear-and-tear arthritis, osteoarthritis causes joint pain, swelling, and deformity. Osteoarthritis is the most common type of arthritis
How do glucosamine and chondroitin work?
Glucosamine and chondroitin are two molecules that make up the type of cartilage found within joints. Inside your joints, cartilage undergoes a constant process of breakdown and repair. However, to be properly repaired, the building blocks of cartilage must be present and available. The theory behind using the glucosamine and chondroitin joint supplements is that more of the cartilage building blocks will be available for cartilage repair.
- Glucosamine is a precursor to a molecule called a glycosaminoglycan-this molecule is used in the formation and repair of cartilage.
- Chondroitin is the most abundant glycosaminoglycan in cartilage and is responsible for the resiliency of cartilage.
Treatment with these joint supplements is based on the theory that oral consumption of glucosamine and chondroitin may increase the rate of formation of new cartilage by providing more of the necessary building blocks.
Do glucosamine and chondroitin supplements increase cartilage formation?
While it is an interesting theory, oral consumption of glucosamine and chondroitin has not been shown to alter the availability of these cartilage building blocks inside an arthritic joint. It has not been shown that consumption of joint supplements increases the quantity of these cartilage building blocks within any joint.
What research has investigated glucosamine and chondroitin?
There have been numerous studies to examine the treatment effects of glucosamine and chondroitin over short periods of time. Most of these studies last only one to two months; however, they have indicated that patients experienced more pain reduction when taking glucosamine and chondroitin than patients receiving a placebo. The improvement experienced by these patients was similar to improvements experienced by patients taking nonsteroidal anti-inflammatory medications (NSAIDs) that have been a mainstay of non-operative arthritis treatment. The difference is that NSAIDs carry an increased risk of side effects including gastrointestinal complaints and bleeding.
The joint supplements glucosamine and chondroitin have few side effects, and thus their use would be preferred if the effects of pain reduction were indeed the same. Furthermore, there is an indication that NSAIDs may increase the progression of arthritis, whereas glucosamine and chondroitin may offer a more protective effect to the cartilage surface.
There have been some recent investigations that are focusing on the two primary problems of earlier studies into the supplements glucosamine and chondroitin:
- Studying more patients
- Following these patients for a longer period of time
Because osteoarthritis is a chronic disease that progresses slowly over time, in order to test any treatment, a long period of follow-up is necessary. In one recent study, the effects of chondroitin in 372 patients over a minimum three month period was investigated. This study, which combined the data from other smaller studies, found that patients did have an improvement in their symptoms of pain.
There have also been long-term studies lasting over one year into the effects of glucosamine. These studies also have shown encouraging results. A presentation at the 1999 meeting of the American College of Rheumatology illustrated the findings of a three year long European study that compared the effects of glucosamine versus placebo in about 200 patients. The group of patients taking glucosamine had less pain and better x-ray findings than the group of patients taking the placebo.
Should I be taking glucosamine and chondroitin?
Again, the results of studies investigating glucosamine and chondroitin have been encouraging, but have not passed the test of a well-designed study to be accepted into the primary treatment plan for osteoarthritis. Furthermore, because these are unregulated supplements, a particular brand of glucosamine or chondroitin may or may not be of satisfactory quality.
Ultimately, what patients should understand, is that glucosamine and chondroitin have shown encouraging evidence that these supplements can provide help with treating osteoarthritis. However, these studies have ranged from poor to satisfactory in quality, and in order to be accepted as an effective treatment for osteoarthritis, more research must be completed.
What is known, is that there are effective treatments for osteoarthritis that every patient should be using before considering these supplements. Specifically, recommendations for weight control, exercise, proper use of medications, and joint protection are known to minimize the progression and improve symptoms of osteoarthritis. These steps must be taken by all arthritis patients for optimal treatment to take place.
When it comes to choosing joint supplements there are many options. Use caution when choosing both the supplement and brand. Recent studies have shown that some brands come far short of the label claims. In one study of eleven chondroitin products, tests showed four of the products contained less than half the stated amount of chondroitin. How do you choose a product? The Arthritis Foundation says to pick the most reputabile brand–don’t try to save with a cheaper imitation.
Top 4 Joint Supplements
1. Glucosamine
Glucosamine is an amino acid that is naturally produced in the body. Glucosamine is a precursor to a molecule used in the formation and repair of cartilage. Treatment with glucosamine is based on the idea that oral consumption of the substance may increase to rate of formation of new cartilage by providing more of the necessary building blocks. The recommended dose of glucosamine in 1500mg each day for one to two months. Ongoing treatment if often continued if results are favorable.
2. Chondroitin
Chondroitin is the most abundant glycosaminoglycan in cartilage and is partly responsible for the resiliency of cartilage. Chondroitin is also important in preventing the action of enzymes that destroy cartilage. The recommended dose of chondroitin is 800 mg each day (400 mg twice daily) for one to two months. Ongoing treatment if often continued if results are favorable. Most commonly chondroitin is take in combination with glucosamine.
3. MSM
Methylsulfonylmethane (MSM) is taken because some believe it helps support health ligaments. While glucosamine and chondroitin have not undergone extensive clinical testing, MSM has not undergone any significant test to support its use. The theory is that the sulfer in MSM helps the body maintain healthy, flexible ligaments.
4. Combination Supplements
Combinations of both glucosamine and chondroitin, and all three aforementioned supplements, are readily available. These combinations are usually cheaper than the individual medications and certainly easier to take. Use caution when taking these medications, and check with your doctor before starting these drugs.
